Wanggongchang Explosion (王恭廠大爆炸)
"An unexplained catastrophic explosion that occurred in 1626 AD during the late reign of Tianqi Emperor, at the heavily populated Ming China capital Beijing, and had reportedly killed around 20,000 people. The nature of the explosion is still unclear to this day, as it is estimated to have released energy equivalent to about 10-20 kiloton of TNT, similar to that of the Hiroshima bombing."